Medical Journal Citations on Neuropathy, Sound Therapy, and Cellular Senescence

This document provides a curated list of medical journal citations related to the management of neuropathy through meditation and sound-based therapies, as well as the emerging role of senescent cells in neuropathic pain and nerve damage.

Meditation and Mindfulness for Neuropathy

Mindfulness-based interventions are increasingly being studied for their potential to alleviate the symptoms of chronic neuropathic pain. These approaches focus on improving coping skills, reducing pain intensity, and enhancing the overall quality of life for individuals with neuropathy.

Babos, C. I., et al. (2024). Meditation-based therapies for chronic neuropathy: a systematic review and meta-analysis. Cureus, 16(8), e67099. [Cited by 4]
A meta-analysis finding that meditation groups experienced significantly lower pain, anxiety, and depression scores at 1 to 1.5 months of follow-up.

Nathan, H. J., et al. (2017). Randomized trial of the effect of mindfulness-based stress reduction on pain-related disability, pain intensity, health-related quality of life, and A1C in patients with painful diabetic peripheral neuropathy. Clinical Diabetes, 35(5), 294-301. [Cited by 78]
This randomized trial demonstrated that Mindfulness-Based Stress Reduction (MBSR) led to improved function, better health-related quality of life, and reduced pain intensity for patients with painful diabetic peripheral neuropathy.

Rozworska, K. A., et al. (2020). Mediators and moderators of change in mindfulness-based stress reduction for painful diabetic peripheral neuropathy. Journal of Behavioral Medicine, 43, 149-159. [Cited by 15]
Highlights that while painful diabetic peripheral neuropathy (PDPN) has a modest response to medication, MBSR can lead to significant improvements.

Kandah, M., Wilson, C., & Pilitsis, J. G. (2023). Role of integrative health on neuropathic pain. Current Pain and Headache Reports, 27, 53-61. [Cited by 9]
This review discusses how mindfulness meditation can be effectively used as a therapeutic approach for chronic pain management.

Sound-Based and Electromagnetic Therapies for Neuropathy

Emerging research is exploring the use of sound waves and electromagnetic fields to treat neuropathic pain and promote nerve regeneration. These non-invasive therapies are being investigated for their potential to provide pain relief and support the body’s natural healing processes.

Weintraub, M. I., et al. (2004). Pulsed magnetic field therapy in refractory neuropathic pain secondary to peripheral neuropathy: electrodiagnostic parameters—pilot study. Neurorehabilitation and Neural Repair, 18(1), 42-46. [Cited by 81]
A pilot study showing that Pulsed Electromagnetic Field (PEMF) therapy applied to the feet provided short-term analgesic effects in over 50% of individuals with refractory neuropathic pain.

Fontana, F., et al. (2024). Pulsed electromagnetic field stimulation enhances neurite outgrowth and promotes neuronal differentiation in human iPSC-derived neurons. Bioelectricity, 6(1), 1-11. [Cited by 11]
This study suggests that PEMF stimulation is a promising, minimally invasive approach for nerve regeneration.

Ni, L., et al. (2023). Electrical stimulation therapy for peripheral nerve injury. Frontiers in Neurology, 14, 1081458. [Cited by 79]
This article reviews various methodologies for using electrical stimulation as an effective tool in the rehabilitation of peripheral nerve injuries.

Cellular Senescence and Neuropathy

Cellular senescence, the process where cells stop dividing and accumulate in tissues, is increasingly being linked to age-related diseases, including neuropathy. Research into senolytics—drugs that can clear these senescent cells—is opening up new therapeutic possibilities for treating nerve damage and neuropathic pain.

Acklin, S., et al. (2020). Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice. Scientific Reports, 10, 14170. [Cited by 76]
Demonstrates that chemotherapy-induced peripheral neuropathy is associated with the accumulation of senescent-like cells and that their removal can alleviate symptoms.

Borgonetti, V., et al. (2022). Microglia senescence is related to neuropathic pain-associated comorbidities in the spared nerve injury model. Pain, 163(12), e1245-e1261. [Cited by 20]
This study highlights the increased presence of senescent microglia in neurological diseases and their contribution to neuropathic pain.

Du, J., et al. (2023). Astrocyte senescence-like response related to peripheral nerve injury-induced neuropathic pain. Cellular & Molecular Biology Letters, 28, 64. [Cited by 27]
Explores the link between the senescence of astrocytes (a type of brain cell) and the development of neuropathic pain disorders following nerve injury.

Donovan, L. J., et al. (2025). Aging and injury drive neuronal senescence in the dorsal root ganglia. Nature Neuroscience, 28, 256-269. [Cited by 18]
Shows that both aging and injury can drive neuronal senescence and that the depletion of these senescent cells can alleviate peripheral neuropathy.

Lei, S. Y., et al. (2024). Cellular senescence: A novel therapeutic target for central nervous system diseases. Biomedicine & Pharmacotherapy, 179, 117358. [Cited by 10]
This paper discusses how senescent neurons show decreased electrical activity and impaired synaptic plasticity, making cellular senescence a key target for CNS diseases.

Berlanga-Acosta, J. A., et al. (2020). Cellular senescence as the pathogenic hub of diabetes-related wound chronicity. Frontiers in Endocrinology, 11, 573032. [Cited by 99]
This article connects cellular senescence to the vascular defects observed in neuropathic diabetic ulcers, highlighting its role as a pathogenic hub.

Techameena, P., et al. (2024). The single-cell transcriptomic atlas iPain identifies senescent cells as a therapeutic target for chronic pain. Nature Communications, 15, 7707. [Cited by 8]
Identifies a direct connection between cellular senescence and chronic pain, positioning senescent cells as a key therapeutic target.

Nelke, C., et al. (2022). Cellular senescence in neuroinflammatory disease. Trends in Immunology, 43(11), 871-884. [Cited by 34]
This review discusses the link between cellular senescence and chemotherapy-induced peripheral neuropathy (CIPN), further solidifying the role of senescent cells in nerve damage.